The 2021-22 ISL edition is the eighth time Mumbai City FC is going to compete against all the other teams for the top position. They were last season’s winners followed by ATK Mohun Bagan. In the last season, the inclusion of some of the biggest Indian football clubs in the season made it even more thrilling. These clubs, ATK Mohun Bagan and East Bengal made the ISL have a total of 11 teams in last season. However, despite all these, Mumbai City emerged the winners by beating ATK Mohun Bagan 2-1 in the finals.
Mumbai city winning last season brought up the numbers of the clubs that won the ISL championship to 4 teams in all the seven seasons played. The following is the full Mumbai City squad.
| NAME | POSITION OF PLAY | NATIONALITY | AGE |
| Nishit Shetty | Goalie | Indian | 20 years |
| Phurba Lashenpa | Goalie | Indian | 33 years |
| Mohammad Rakip | Defender | Indian | 21 years |
| Tondonba Singh | Defender | Indian | 26 years |
| Amey Ranawade | Defender | Indian | 23 years |
| Mehtab Singh | Defender | Indian | 23 years |
| Mandar Desai | Defender | Indian | 29 years |
| Mourtada Fall | Defender | Senegalese | 33 years |
| Hmingthan Mawia | Defender | Indian | 21 years |
| Bradden Inman | Midfielder | Australian | 29 years |
| Ahmed Jahouh | Midfielder | Moroccan | 33 years |
| Raynier Fernandes | Midfielder | Indian | 25 years |
| Rowlin Borges | Midfielder | Indian | 29 years |
| Pranjal Bhumij | Midfielder | Indian | 22 years |
| Jackichand Singh | Midfielder | Indian | 29 years |
| Vikram Pratap Singh | Midfielder | Indian | 19 years |
| Vignesh Dakshinamurthy | Midfielder | Indian | 23 years |
| Bipin Singh | Midfielder | Indian | 26 years |
| Mohammed Asif Khan | Midfielder | Indian | 20 years |
| Hernan | Midfielder | Spaniard | 31 years |
Mumbai City FC will kick start the 2021-22 ISL tournament by facing it off with FC Goa on the 22nd of November. ATK Mohun Bagan will be looking forward to avenging their loss against Mumbai City and their first leg will be played on December 1st in Fatorda Stadium from 7:30 PM. Below is a full fixture table of the first leg of Mumbai City.
| DATE | TIME(IST) | TEAMS |
| Nov 22nd | 7:30 PM | Mumbai City VS FC Goa |
| Nov 27th | 9:30 PM | Hyderabad VS Mumbai City |
| Dec 1st | 7:30 PM | Mumbai City VS ATK Mohun Bagan |
| Dec 4th | 9:30 PM | Mumbai City VS Bengaluru FC |
| Dec 9th | 7:30 PM | Jamshedpur FC VS Mumbai City |
| Dec 15th | 7:30 PM | Chennaiyin FC VS Mumbai City |
| Dec 19th | 7:30 PM | Kerala Blasters FC VS Mumbai City |
| Dec 27th | 7:30 PM | NorthEast United FC Vs Mumbai City |
| Jan 3rd | 7:30 PM | Mumbai City VS Odisha FC |
| Jan 7th | 7:30 PM | Sc East Bengal VS Mumbai city |
